Sodium Methoxide → HCID 15684565, compound

Participants

Reaction Steps

A mixture of 2-amino-6-[2-(7-chloromethyl-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (0.4 g), and sodium methoxide (0.13 g) in methanol (10 ml) was stirred for 3 hours at 40°-50° C. and the solvent was evaporated in vacuo. The residue was dissolved in a mixture of ethyl acetate and tetrahydrofuran and the mixture was washed with water and dried over magnesium sulfate. Evaporation of the solvent gave a residue, which was purified by silica gel column chromatography eluting with a solution of chloroform and methanol (9:V/V). The fraction containing object compound were concentrated to give 2-amino-6-[2-(7-methoxymethyl-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (0.22 g).

Provenance & Evidence