HCID 15171562, compound → HCID 15684567, compound

Participants

Reaction Steps

10% Palladium on carbon (0.3 g) was added to a solution of 2-amino-6-[2-(7-azidomethyl-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (1.0 g) in methanol (100 ml) and the mixture was subjected to catalytic reduction at ambient temperature under atmospheric pressure of hydrogen gas. The catalyst was removed by filtration and the filtrate was evaporated in vacuo. The residue was purified by alumina column chromatography eluting with a solution of chloroform and methanol (4:1, V/V). The fractions containing object compound was evaporated to give 2-amino-6-[2-(7-aminomethyl-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (0.41 g).

Provenance & Evidence