Dichloromethane → HCID 178423695, compound

Participants

Reaction Steps

The mixture of 2-amino-6-[2-(7-methoxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzothiazole (2.3 g) and boron tribromide (6.4 ml) in dichloromethane (115 ml) was stirred for 20 hours at ambient temperature and the solvent was evaporated in vacuo. A mixture of obtained residue and water was adjusted to pH 7.5 with 20% potassium carbonate aqueous solution and resulting precipitate was collected by filtration and dried. The residue was purified by alumina column chromatography eluting with a solution of chloroform and methanol (4:1, V/V). The fractions containing object compound were concentrated in vacuo. To a mixture of obtained residue and ethanol (3 ml) was added conc. hydrochloric acid (0.2 ml) and the mixture was stirred for 30 minutes at ambient temperature. The resulting precipitate was collected by filtration and dried to give 2-amino-6-[2-(7-hydroxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzothiazole dihydrochloride (0.22 g).

Provenance & Evidence