Hydrochloric Acid → HCID 15684566, compound

Participants

Reaction Steps

The mixture of 2-amino-6-[2-(3-methyl-7-tertbutoxycarbonylaminoimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (0.8 g) and conc. hydrochloric acid (0.9 ml) in ethanol (20 ml) was heated under refluxed for 1 hour. The mixture was ice-cooling and the isolated precipitate was collected by filtration. To a precipitate was added a mixture of ethyl acetate, tetrahydrofuran and water, and the mixture was adjusted to pH 8.5 with 20% aqueous potassium carbonate solution with salting-out technique. The separated organic layer was washed with brine and dried over magnesium sulfate. Evaporation of the solvent gave a residue, which was triturated with a solution of ethyl acetate and diethyl ether, and the precipitate was collected by filtration to give 2-amino-6-[2-(7-amino-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (0.24 g).

Provenance & Evidence