Hydrochloric Acid → HCID 15684574, compound

Participants

Reaction Steps

A mixture of 6-[2-(8-acetylamino-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]-2-aminobenzoxazole (0.6 g) and conc. hydrochloric acid (0.76 ml) in ethanol (12 ml) was refluxed for 7 hours. To the reaction mixture was added ethyl acetate (18 ml) and the resulting precipitate was collected by filtration. A solution of resulting precipitate in water was adjusted to pH 9.0 with 20% aqueous potassium carbonate solution and the precipitate was collected by filtration and dried to give 2-amino-6-[2-(8-amino-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (0.45 g).

Provenance & Evidence