HCID 19823303, compound → HCID 19823321, compound

Participants

Reaction Steps

10% Palladium on carbon (0.2 g) was added to a mixture of 2-amino-6-[2-(3,7-dimethylimidazo[1,2-a]-pyridin-2-yl)ethyl]benzoxazole dihydrochloride (1.0 g) in methanol (70 ml) and the mixture was subjected to catalytic reduction under atmospheric pressure at ambient temperature for 6.5 hours. The catalyst was removed by filtration and the filtrate was evaporated in vacuo. The residue was triturated with ethyl acetate and the precipitate was collected by filtration to give 2-amino-6-[2-(3,7-dimethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole dihydrochloride (0.95 g).

Provenance & Evidence