Formaldehyde → HCID 10358221, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(N-ethylformamido)-6-[2-(2-furyl)ethyl]benzoxazole (1.25 g), 36% formalin (1.83 ml) and dimethylamine hydrochloride (1.79 g) in acetic acid (8.3 ml) was stirred at 80° C. for 6 hours. The solvent was evaporated in vacuo, the residue was mixed with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The extract was washed with water, dried over magnesium sulfate and evaporated in vacuo. The residue was chromatographed on silica gel by eluting with chloroform-methanol (20:1, V/V). The pure base was converted to the maleate in a usual way and the salt was recrystallized from ethyl acetate to give 6-[2-(5-dimethylaminomethylfuran- 2-yl)ethyl]-2-ethylaminobenzoxazole 3/2 maleate (0.38 g).

Provenance & Evidence