反应详情

commercial 2-ethylaniline (50 mL, 0.40 mol) was dissolved in acetic anhydride (160 mL, 1.70 mol) and stirred at room temperature for 2 h. Then the reaction mixture was poured into H2O, the whole was extracted with ethyl acetate (2×200 mL). The combined organic extracts were washed with 5% aqueous NaHCO3, brine, dried (K2CO3), filtered and concentrated to provide the title compound as a white solid (60.0 g, 92%).

1. extractionthe whole was extracted with ethyl acetate (2×200 mL)
2. washThe combined organic extracts were washed with 5% aqueous NaHCO3, brine
3. dry with materialdried (K2CO3)
4. filtrationfiltered
5. concentrationconcentrated