Acetyl chloride → HCID 15684563, compound

Participants

Reaction Steps

Acetyl chloride (1.2 ml) was added to a mixture of 2-amino-6-[2-(7-hydroxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (1.8 g) and triethylamine (2.4 ml) in dichloromethane (36 ml) under ice-cooling and a mixture was stirred for 15 hours at ambient temperature. To the reaction mixture was added a mixture of ethyl acetate and tetrahydrofuran, and the resulting mixture was washed with water. The mixture was dried over magnesium sulfate and evaporated to give 2-amino-6-[2-(7-acetoxy-3-methylimidazo[1,2-a]pyridin-2-yl)ethyl]benzoxazole (0.27 g).

Provenance & Evidence