Acetyl chloride → HCID 15684669, compound

Participants

Reaction Steps

Acetyl chloride (1.5 ml) was dropwise added to a mixture of 2-[2-(4-amino-3-hydroxyphenyl)ethyl]-3,7-dimethylimidazo[1,2-a]pyridine (5.0 g) and sodium bicarbonate (3.0 g) in acetone (30 ml) and water for 10 minutes under ice-cooling and the mixture was stirred for 30 minutes at the same temperature. To the mixture was added a solution of ethyl acetate, tetrahydrofuran and water, and separated organic layer was washed with brine. The mixture was dried over magnesium sulfate and concentrated to give 2-[2-(4-acetamido-3-hydroxyphenyl)ethyl]-3,7-dimethylimidazo[1,2-a]pyridine (3.51 g).

Provenance & Evidence