Formaldehyde → HCID 10062547, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[2-(4-acetamidophenyl)ethyl]furan (0.50 g), 37% formalin (0.26 ml) and dimethylamine hydrochloride (0.27 g) in acetic acid (5 ml) was stirred at ambient temperature for 1 hour and at 50° C. for further 1 hour. The solvent was evaporated in vacuo. The residue was mixed with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The extract was washed with water, dried over magnesium sulfate and evaporated in vacuo to give 2-[2-(4-acetamidophenyl)ethyl]-5-dimethylaminomethylfuran (0.57 g) as an oil.

Provenance & Evidence