Ethyl Acetate → HCID 54000152, compound

Participants

Reaction Steps

A mixture of 4-bromo-1-(3-benzyloxy-4-nitrophenyl)but-1-en-3-one (55.0 g) and 2-aminopyridine (42.3 g) in acetonitrile (380 ml) was stirred for 4 hours at ambient temperature. Ethyl acetate was added to the reaction mixture and the precipitate was collected by filtration. A mixture of water and ethyl acetate was added to the precipitate and the mixture was adjusted to pH 7.0 with 20% potassium carbonate. The precipitate was collected by filtration and washed with water to give 2-[2-(3-benzyloxy-4-nitrophenyl)vinyl]imidazo[1,2-a]pyridine (40.1 g).

Provenance & Evidence