HCID 19823335, compound → HCID 15684639, compound

Participants

Reaction Steps

10% Palladium on carbon (3.0 g) was added to a mixture of 2-[2-(3-benzyloxy-4-nitrophenyl)ethyl]-3-methylimidazo[1,2-a]pyridine (6.5 g) in a mixture of methanol and tetrahydrofuran, and the mixture was subjected to catalytic reduction under. atmospheric pressure for 3 hours at ambient temperature. The catalyst was removed by filtration and the filtrate was evaporated in vacuo. The residue was purified by a column chromatography on silica gel, and eluted with a mixture of chloroform and methanol (9:1, V/V). The eluted fast fractions containing the desired product were collected and evaporated in vacuo to give 2-[2-(4-amino-3-hydroxyphenyl)ethyl]-3-methylimidazo[1,2-a]pyridine (1.37 g).

Provenance & Evidence