Chloroform → HCID 178436799, compound

HRID 72820Notes

Reaction equation

HRID 72820 reaction equation
O.[I-:2].[I-].[I-].[I-].[CH2:6]([C:8]1[C:21]2[C:12](=[S+:13][C:14]3[C:19]([N:20]=2)=[C:18]([CH3:22])[CH:17]=[CH:16][CH:15]=3)[CH:11]=[CH:10][CH:9]=1)[CH3:7].[CH2:23]([C:25]1[C:38]2[C:29](=[S+:30][C:31]3[C:36]([N:37]=2)=[C:35]([CH3:39])[CH:34]=[CH:33][CH:32]=3)[CH:28]=[CH:27][CH:26]=1)[CH3:24].[CH2:40]([C:42]1[C:55]2[C:46](=[S+:47][C:48]3[C:53]([N:54]=2)=[C:52]([CH3:56])[CH:51]=[CH:50][CH:49]=3)[CH:45]=[CH:44][CH:43]=1)[CH3:41].C(C1[C:72]2C(=[S+]C3[C:70]([N:71]=2)=C(C)C=CC=3)C=CC=1)C.C(Cl)(Cl)Cl>>[I-:2].[I-:2].[I-:2].[CH2:6]([C:8]1[C:21]2[C:12](=[S+:13][C:14]3[C:19]([N:20]=2)=[C:18]([CH3:22])[CH:17]=[CH:16][CH:15]=3)[CH:11]=[C:10]([N:37]([CH3:38])[CH3:36])[CH:9]=1)[CH3:7].[CH2:40]([C:42]1[C:55]2[C:46](=[S+:47][C:48]3[C:53]([N:54]=2)=[C:52]([CH3:56])[CH:51]=[CH:50][CH:49]=3)[CH:45]=[C:44]([N:71]([CH3:72])[CH3:70])[CH:43]=1)[CH3:41].[CH2:23]([C:25]1[C:38]2[C:29](=[S+:30][C:31]3[C:36]([N:37]=2)=[C:35]([CH3:39])[CH:34]=[CH:33][CH:32]=3)[CH:28]=[C:27]([N:20]([CH3:21])[CH3:19])[CH:26]=1)[CH3:24]

Participants

3

Reactant 2

HCID 6212ChloroformHCID 866670301-Ethyl-9-methylphenothiazin-5-ium tetraiodide hydrate

Product 1

HCID 178436799HCID 178436799, compound

Procedure

To the stirred mixture of 1-ethyl-9-methylphenothiazin-5-ium tetraiodide hydrate (383 mg, 0.5 mmol) in anhydrous CHCl3 (20 mL) dimethylamine (0.5 mL, 1.0 mmol, 2 m solution in THF) was added drop wise over 4 h. The resulting mixture was stirred at room temperature overnight, concentrated to dryness.

Workup

  1. additionwas added drop wise over 4 h
  2. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-3d559cebc8914b7faf1a56706332631a
Source dataset
uspto-grants-2014_09
Patent number
US08828986B2

Reaction notes

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