HCID 54000152, compound → HCID 15171525, compound

Participants

Reaction Steps

A solution of 2-[2-(3-benzyloxy-4-nitrophenyl)vinyl]imidazo[1,2-a]pyridine (40 g) in ethanol (600 ml) was hydrogenated over 10% palladium on carbon (10 g) at 4 to 6 atmospheric pressure of hydrogen gas for 4 hours at 40° to 70° C. The catalyst was removed by filtration an the filtrate was evaporated in vacuo to give a crystalline residue, which was washed with diethyl ether and dried to give 2-[2-(4-amino-3-hydroxyphenyl)ethyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine (19.0 g).

Provenance & Evidence