p-Toluenesulfonic acid → HCID 67930799, compound

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Reaction Steps

A solution of this compound (9.6 g) in bis-(2-methoxyethyl) ether (100 ml) containing anhydrous p-toluenesulphonic acid (500 mg) was heated under reflux, while passing a stream of nitrogen through the condenser, for 1 h. The cooled solution was neutralised with triethylamine and evaporated at 50° C. and 1 torr to a dark brown oil. Purification by flash chromatography on silica gel gave the title compound (4.5 g, 57%), identical by melting point, optical rotation, 1H-nmr, and 13C-nmr to the compound described in Preparative Example 1.

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