反应详情

温度

65 °C

Acetic anhydride (57 mL, 0.6 mol) was added slowly, over approximately 40 min., to stirred 2-fluoroaniline (55.7 g, 0.5 mol) under cooling (water bath) to maintain the reaction temperature at 60-70° C. After 10 more hours the reaction mixture was poured into H2O, the whole was extracted with ethyl acetate (2×300 mL). The combined organic extracts were washed with 5% aqueous NaHCO3, brine, dried (K2CO3), filtered and concentrated to provide the title compound as a white solid (67.0 g, 88%).

1. extractionthe whole was extracted with ethyl acetate (2×300 mL)
2. washThe combined organic extracts were washed with 5% aqueous NaHCO3, brine
3. dry with materialdried (K2CO3)
4. filtrationfiltered
5. concentrationconcentrated