Cesium carbonate → HCID 70895770, compound

Participants

Role	Name	HCID	Charge
Reactant	Cesium carbonate	HCID 10796	—
Reactant	Pyrrolidine	HCID 31268	—
Reactant	Binap, (A+-)-	HCID 634876	—
Reactant	HCID 70895768	HCID 70895768	—
Catalyst	(1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium	HCID 6505921	—
Product	HCID 70895770	HCID 70895770	—

Reaction Steps

To a stirred solution of 3-morpholino-1-fluoro-7-bromo-10-Boc-phenothiazine (150 mg, 0.3 mmol) in touene (10 mL) Pd(dba)2 (5.8 mg, 0.01 mmol), BINAP (6.3 mg, 0.01 mmol), Cs2CO3 (326 mg, 1.0 mmol) and pyrrolidine (42.6 mg, 0.6 mmol) were added. The mixture was refluxed for 24 h. After that reaction mixture was filtered, solvent was removed under vacuum. Product was used without additional purification.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08828986B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-e747b531ab19433e97189060ba8c624b
Source note	uspto-grants-2014_09