反应详情

A solution of bromine (8 ml) in dichloromethane (40 ml) was added at 10° C. to a solution of 1-[1-(4-chlorophenyl)cyclobutyl]ethanone (27.8 g) in methanol (30 ml). The mixture was stirred for 15 minutes and poured into a mixture of ice and water. The resulting mixture was extracted with dichloromethane. The extract was washed with water, dried and evaporated to yield an oil which was distilled (145°-160° C./1mm Hg) to give 1-[1-(4-chlorophenyl)cyclobutyl]-2-bromoethanone.

1. extractionThe resulting mixture was extracted with dichloromethane
2. washThe extract was washed with water
3. customdried
4. customevaporated
5. customto yield an oil which
6. distillationwas distilled (145°-160° C./1mm Hg)