Methanol → 2-[1-(4-Chlorophenyl)cyclobutyl]-2,2-dimethoxyethanol

Participants

Reaction Steps

A solution of 1-[1-(4-chlorophenyl)cyclobutyl]-2-bromoethanone (3 g) in methanol (10 ml) was added to sodium methoxide prepared by the reaction of sodium (0.46 g) and methanol (20 ml) and the mixture was stirred for two hours, and then poured into water. The aqueous mixture was extracted with ether and the extract dried and evaporated to give 2-[1-(4-chlorophenyl)cyclobutyl]-2,2-dimethoxyethanol (m.p. 73°-74° C.).

Provenance & Evidence