HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 70895815, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | Tert-butyl 1,4-diazepane-1-carboxylate | HCID 2756058 | — |
| Reactant | 3,7-Dibromo-1-fluoro-10-Boc-phenothiazine | HCID 68227324 | — |
| Product | HCID 70895815 | HCID 70895815 | — |
Reaction Steps
To a stirred solution of 3,7-dibromo-1-fluoro-10-Boc-phenothiazine (950 mg, 2.0 mmol) in toluene (30 mL) Pd2(dba)3 (46 mg, 0.05 mmol), BINAP (31 mg, 0.05 mmol), Cs2CO3 (652 mg, 2.0 mmol) and N-Boc-homopiperazine (1-Boc-1,4-diazepane) (400 mg, 2.0 mmol) were added. The mixture was refluxed for 24 h. After that reaction mixture was filtered, solvent was removed under vacuum. Product was used without additional purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828986B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-5c2761e4ae084696bc051f8a71c12dac |
| Source note | uspto-grants-2014_09 |