HCID 53666228, compound → HCID 53880921, compound

Participants

Reaction Steps

Into 250 ml of concentrated hydrochloric acid, 13 g of 4-cyano-4-(4-pyridyl)pimelic acid methyl ester was dissolved, and the solution was refluxed for 14 hours. Hydrochloric acid was distilled off under reduced pressure and the residue was dissolved in 200 ml of methanol. To this solution, there was added 1 ml of concentrated sulfuric acid and the mixture was refluxed for 4 hours. After 3 g of sodium bicarbonate was added, methanol was distilled off and 150 ml of water and 150 ml of ethyl acetate were added. Further, 25 g of sodium bicarbonate was gradually added. The organic layer was removed, washed with 50 ml of saturated aqueous solution of sodium chloride, and dried over anhydrous sodium sulfate. After the solvent was distilled off, there was obtained 26 g of 4-(4-pyridyl)pimelic acid methyl ester as an oily material.

Provenance & Evidence