3-Nitrobenzaldehyde → HCID 86745039, compound

Participants

Reaction Steps

A solution of 9.07 g (0.06 mole) of m-nitrobenzaldehyde, 15.00 g (0.06 mole) of 2-picolinoylaminoethyl acetoacetate, 12.24 g (0.06 mole) of 3-nitrooxypropyl 3-aminocrotonate and 1.74 g (0.012 mole) of piperidinium acetate in 200 ml of 2-propanol was refluxed for 4 hours. After the reaction, the solvent was evaporated, and the residue was purified by silica gel column chromatography [eluent; ethyl acetate hexane (1:3)] to give 20.45 g of the title compound.

Provenance & Evidence