Thionyl Chloride → 3-(Methylsulfanyl)thiophene-2-carbonyl chloride
Reaction equation
[CH3:1][S:2][C:3]1[CH:7]=[CH:6][S:5][C:4]=1[C:8]([OH:10])=O.S(Cl)([Cl:13])=O>>[CH3:1][S:2][C:3]1[CH:7]=[CH:6][S:5][C:4]=1[C:8]([Cl:13])=[O:10]Participants
Procedure
3-Methylthio-2-thiophenecarboxylic acid (prepared according to Carpenter, A. J., et al., Tetrahedron Letters 26:1777 (1985)) (2.61 g, 15.0 mmoles) was reacted with 10 ml of thionyl chloride to give 2.83 g of crude 3-methylthio-2-thiophenecarbonyl chloride as a light yellow solid. The acid chloride was then coupled to 2.57 g (12.2 mmoles) 5-chloro-2-oxindole-1-carboxamide in the presence of 4.47 g (36.6 mmoles) 4-(N,N-dimethylamino)pyridine as described in Example 32 to give 3.73 g of crude product as an orange solid. The product was partially purified by recrystallization from 2-butanone to give 1.44 g of greenish-yellow solid. Pure title compound was obtained by a second recrystallization from ethyl acetate to give 0.92 g (2.51 mmoles, 21% yield) as a yellow solid. The pure compound initially melts at 178° C. then resolidifies and melts again above 275° C. (dec.).
Sources & evidence
- ORD record
- ord-4909d3bd5c3d462586f567c8b7186bc5
- Source dataset
- uspto-grants-1991_09
- Patent number
- US05047554
Reaction notes
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