Acetyl chloride → N-[2-(Acetyloxy)ethyl]-N,N-dimethyldodecan-1-aminium bromide

Participants

Reaction Conditions

Reaction Steps

In a reaction vessel was placed 13.14 grams of dodecyldimethyl 2-hydroxyethylammonium bromide, 21.22 grams of acetone solvent and 4.72 grams of sodium carbonate. While stirring under nitrogen, 3.27 grams of acetyl chloride was added dropwise. Gas evolution occurred. The mixture was then refluxed (ca. 60° C.) for 6 hours. The solvent was removed under vacuum. The residue was extracted with isopropanol to dissolve the quat and the solution was filtered hot to remove sodium chloride and sodium carbonate. The filtrate was evaporated under vacuum leaving as the product dodecyldimethyl 2-acetyloxyethylammonium bromide.

Provenance & Evidence