反应详情

A mixture of 2-nitro-4-carboxyaniline (0.52 g), heptadecanol (0.7 g) and dimethylaminopyridine (20 mg) in dichloromethane (20 ml) was prepared and dicyclohexyldicarbodiimide (0.62 g) was added. The mixture was stirred for 48 hours and filtered. After separating between chloroform and 3% caustic soda solution the organic phase was washed with water, dried with magnesium sulphate and the solvent removed to leave a yellow solid. The solid was purified by chromatography to give a yellow solid which was recrystallised from 50:50 chloroform-hexane (yield: 0.85 g, m.p. 103°-105° C.).

1. customwas prepared
2. filtrationfiltered
3. customAfter separating between chloroform and 3% caustic soda solution the organic phase
4. washwas washed with water
5. dry with materialdried with magnesium sulphate
6. customthe solvent removed
7. customto leave a yellow solid
8. customThe solid was purified by chromatography
9. customto give a yellow solid which
10. customwas recrystallised from 50:50 chloroform-hexane (yield: 0.85 g, m.p. 103°-105° C.)