HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiazole → 1-Hexadecylthio-2-methoxy-3-(3-thiazoliopropylsulfonylamino)propane iodide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiazole | HCID 9256 | — |
| Reactant | 1-Hexadecylthio-3-(3-iodopropylsulfonylamino)-2-methoxypropane | HCID 14835023 | — |
| Product | 1-Hexadecylthio-2-methoxy-3-(3-thiazoliopropylsulfonylamino)propane iodide | HCID 67903006 | 56% |
Reaction Steps
A solution of 600 mg (1.04 mM) of 1-hexadecylthio-3-(3-iodopropylsulfonylamino)-2-methoxypropane IIa2 in 5 ml of thiazole is stirred at 60° C. for 6 hours. After thiazole is evaporated, the residue is washed with ether and recrystallized from acetone to give 387 mg (0.584 mM) of 1-hexadecylthio-2-methoxy-3-(3-thiazoliopropylsulfonylamino)propane iodide Ia9 in 56% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05047540 |
| Source dataset | uspto-grants-1991_09 |
| ORD ID | ord-67ab0bfd55244b41b514a88a82774260 |
| Source note | uspto-grants-1991_09 |