2-tert-Butoxycarbonylamino-3-octadecylcarbamoyloxypropylamine → 2-Tert-butoxycarbonylamino-3-(3-chloropropylsulfonylamino)-1-octadecylcarbamoyloxypropane

HRID 728448Notes

Reaction equation

HRID 728448 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]([CH2:12][O:13][C:14](=[O:34])[NH:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[CH2:10][NH2:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:35][CH2:36][CH2:37][CH2:38][S:39](NCC(OC)CSCCCCCCCCCCCCCCCC)(=[O:41])=[O:40]>>[C:1]([O:5][C:6]([NH:8][CH:9]([CH2:10][NH:11][S:39]([CH2:38][CH2:37][CH2:36][Cl:35])(=[O:41])=[O:40])[CH2:12][O:13][C:14](=[O:34])[NH:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 148350012-tert-Butoxycarbonylamino-3-octadecylcarbamoyloxypropylamineHCID 14835022HCID 14835022, compound

Product 1

HCID 156673052-Tert-butoxycarbonylamino-3-(3-chloropropylsulfonylamino)-1-octadecylcarbamoyloxypropane

Procedure

2-tert-Butoxycarbonylamino-3-octadecylcarbamoyloxypropylamine IVe2 is allowed to react by the same procedure as described in (4). m.p. 112°-115° C. The summary of the experimental condition and the physical data of the product are listed in Table 7.

Workup

  1. customto react by the same procedure

Sources & evidence

ORD record
ord-b15b6899d97b4f1fbacea271436b478f
Source dataset
uspto-grants-1991_09
Patent number
US05047540

Reaction notes

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