HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid monohydrate → 3-Hexadecylthio-2-(3-isoxazolyloxy)propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | 3-hexadecylthio-2-(5-methyl-1H-tetrazol-1-yl)propanol | HCID 14834985 | — |
| Reactant | 1-Hexadecylthio-2-(3-isoxazolyloxy)-3-triphenylmethoxypropane | HCID 19884228 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | 3-Hexadecylthio-2-(3-isoxazolyloxy)propanol | HCID 14834991 | 94% |
Reaction Steps
A mixture of 7.30 g (11 mM) of 1-hexadecylthio-2-(3-isoxazolyloxy)-3-triphenylmethoxypropane 5j and 433 mg (2.3 mM) of p-toluenesulfonic acid monohydrate in 150 ml of methanol-tetrahydrofuran (1:1) mixture by the same procedure as described in (81) to give 4.25 g of the titled compound Vj1 (94% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05047540 |
| Source dataset | uspto-grants-1991_09 |
| ORD ID | ord-c835450f993c4681acdb33f14172a6f8 |
| Source note | uspto-grants-1991_09 |