HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium azide → 1-Azido-2-cyanomethyl-3-hexadecyloxypropane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium azide | HCID 88163 | — |
| Reactant | 3-Azido-1-hexadecylthio-2-methoxycarbonylaminopropane | HCID 14835094 | — |
| Reactant | 2-Cyanomethyl-3-hexadecyloxypropyl methanesulfonate | HCID 23056543 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Azido-2-cyanomethyl-3-hexadecyloxypropane | HCID 19884208 | 96.1% |
Reaction Steps
Using 4.9 g (100 mM) of lithium azide, crude product of 2-cyanomethyl-3-hexadecyloxypropyl methanesulfonate Vn1a obtained in the previous reaction in 30 ml of dimethylformamide is converted by the same procedure as described in the (52) and 3.504 g (96.1% yield) of the titled compound Vn1a is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05047540 |
| Source dataset | uspto-grants-1991_09 |
| ORD ID | ord-7cb9f55e51c74e0c95a6d77d24ad97fe |
| Source note | uspto-grants-1991_09 |