Sodium Methoxide → HCID 14835089, compound

HRID 728510Notes

Reaction equation

HRID 728510 reaction equation
C(O[CH2:10][CH2:11][CH2:12][CH:13]([CH2:23][S:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH2:14][NH:15][S:16]([CH2:19][CH2:20][CH2:21][Cl:22])(=[O:18])=[O:17])(=O)C1C=CC=CC=1.C[O-].[Na+].ClCCCS(NCC(CC(O)C)COC(=O)NCCCCCCCCCCCCCCCCCC)(=O)=[O:49]>CO>[Cl:22][CH2:21][CH2:20][CH2:19][S:16]([NH:15][CH2:14][CH:13]([CH2:12][CH:11]([OH:49])[CH3:10])[CH2:23][S:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])(=[O:18])=[O:17]

Participants

5

Reactant 3

HCID 10942334Sodium MethoxideHCID 14835081HCID 14835081, compoundHCID 19884264HCID 19884264, compound

Product 1

HCID 14835089HCID 14835089, compoundYield 54.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A mixture of 1.24 g (2.0 mM) of 2-(benzoyloxypropan-1-yl)-1-(3-chloropropylsulfonylamino)-3-n-hexadecylthiopropane m14 and 0.77 ml (2 mM) of 5.18 M/L sodium methoxide in methanol solution in 50 ml of methanol is allowed to react by the same procedure as described in (131) and 562 mg (54.5% yield) of the titled compound m15 is obtained.

Workup

  1. customto react by the same procedure

Sources & evidence

ORD record
ord-cf086d0f7c734375b260ca83963bb302
Source dataset
uspto-grants-1991_09
Patent number
US05047540

Reaction notes

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