Dimethyl Sulfoxide → HCID 14835090, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled solution of 0.19 ml (1.33 mM) of trifluoroacetic anhydride in 20 ml of dichloromethane at -78° C. is added 0.19 ml (2.66 mM) of dimethylsulfoxide and the mixture is stirred at -78° C. for 5 minutes. To the reaction mixture is added a solution of 428 mg (0.83 mM) of 1-(3-chloropropylsulfonylamino)-2-(2-hydroxypropan-1-yl)-3-n-hexadecylthiopropane m15 in 2 ml of dichloromethane with stirring and the mixture is stirred at -70° C. for an additional 15 minutes. 3.50 ml (24.9 mM) of triethylamine is added and the mixture is allowed to react by the same procedure as described in (132) and 213 mg (41.6% yield) of the titled compound IIIm2 is obtained.

Provenance & Evidence