Oxygen → 2-Cyclohexylpropionic acid

HRID 728539Notes

Reaction equation

HRID 728539 reaction equation
[CH:1]1([CH:7]([CH3:10])[CH:8]=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[O:11]=O>>[CH:1]1([CH:7]([CH3:10])[C:8]([OH:11])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 977OxygenHCID 95560Cyclohexaneacetaldehyde, .alpha.-methyl-

Product 1

HCID 998162-Cyclohexylpropionic acidYield 35%

Procedure

Into a 500 ml round bottom flask was charged 300 g of 2-cyclohexylpropanal and was fed a stream of oxygen at a rate of 100 ml per minute at 60° C. for 80 hours through a sintered liquid filter for liquid chromatography. The reaction mixture was analyzed by means of gas chromatography and confirmed that 2-cyclohexylpropionic acid was obtained in an yield of 65% and 35% of the 2-cyclohexylpropanal remained unreacted in the reaction mixture.

Workup

  1. customat 60° C.
  2. customfor 80 hours
  3. filtrationfilter for liquid chromatography

Sources & evidence

ORD record
ord-d93f7887befb4bb0942e6b57139d15c6
Source dataset
uspto-grants-1991_09
Patent number
US05049544

Reaction notes

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