4-Hydroxy-4-methylcyclohexanone → (4-Methoxy-4 methyl-cyclohexylidene)-acetic acid methyl ester

Participants

Reaction Conditions

Reaction Steps

A mixture of trimethyl phosphonoacetate (9.11 mL, 56 mmol) and (40 mL, 64 mmol) of n-BuLi (1.6N) in DME (60 mL) is stirred for 10 minutes at 0° C. 4-Hydroxy-4-methyl-cyclohexanone (8 g, 56 mmol) was added and the mixture stirred 2.5 hours at 0° C. until TCL indicated complexion of the reaction. Product was obtained after extraction with dichloromethane (7.71 g, 69%).

Provenance & Evidence