Acetylpyrazine → Propanoic acid [1-(2-pyrazinyl)ethylidene]hydrazide

HRID 728545Notes

Reaction equation

HRID 728545 reaction equation
[C:1]([C:4]1[CH:9]=[N:8][CH:7]=[CH:6][N:5]=1)(=O)[CH3:2].[C:10]([NH:14][NH2:15])(=[O:13])[CH2:11][CH3:12]>C(O)C>[N:5]1[CH:6]=[CH:7][N:8]=[CH:9][C:4]=1[C:1](=[N:15][NH:14][C:10](=[O:13])[CH2:11][CH3:12])[CH3:2]

Participants

4

Reactant 2

HCID 30914AcetylpyrazineHCID 79890Propionylhydrazine

Product 1

HCID 54558617Propanoic acid [1-(2-pyrazinyl)ethylidene]hydrazideYield 64.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 6.11 gm (0.05 mole) of 2-acetylpyrazine, 4.41 gm (0.05 mole) of propanoic acid hydrazide and 100 ml of absolute ethanol is refluxed 10 hr. The mixture is cooled. The white crystals which deposit are collected and dried to yield 6.17 gm (64%) of the title compound having a melting point of 181.3° C.

Workup

  1. temperatureis refluxed 10 hr
  2. temperatureThe mixture is cooled
  3. customThe white crystals which deposit are collected
  4. customdried

Sources & evidence

ORD record
ord-634a163bfca84dbcb8aac450056b0f69
Source dataset
uspto-grants-1991_09
Patent number
US05049561

Reaction notes

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