反应详情

Ethyl 8-methoxy-4-chloroquinoline-3-carboxylate (1.5 g, 0.0056 mol) and 4-methoxy-3-aminothiophene (1.46 g, 0.0112 mol) in 1,4 dioxan (20 ml) were heated under reflux for 4 hours. The solid which had formed was collected by filtration and dried. The solid was dissolved in chloroform, washed with sodium carbonate solution (50 ml), then water, dried over magnesium sulphate, filtered and evaporated under reduced pressure to give a yellow solid.

1. temperatureunder reflux for 4 hours
2. customThe solid which had formed
3. filtrationwas collected by filtration
4. customdried
5. dissolutionThe solid was dissolved in chloroform
6. washwashed with sodium carbonate solution (50 ml)
7. dry with materialwater, dried over magnesium sulphate
8. filtrationfiltered
9. customevaporated under reduced pressure
10. customto give a yellow solid