153025-28-6 → HCID 178453891, compound

HRID 72859Notes

Reaction equation

HRID 72859 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][N:9]=[C:8]([CH:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[C:7]=2[CH:17]=1.[C:18]([O:22][C:23](=[O:34])[NH:24][C@H:25]1[CH2:30][CH2:29][C@H:28]([CH2:31][CH:32]=O)[CH2:27][CH2:26]1)([CH3:21])([CH3:20])[CH3:19]>>[C:18]([O:22][C:23](=[O:34])[NH:24][C@H:25]1[CH2:26][CH2:27][C@H:28]([CH2:31][CH2:32][N:14]2[CH2:13][CH2:12][CH:11]([C:8]3[C:7]4[CH:17]=[C:3]([Cl:2])[CH:4]=[CH:5][C:6]=4[O:10][N:9]=3)[CH2:16][CH2:15]2)[CH2:29][CH2:30]1)([CH3:21])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 21471781153025-28-6HCID 178453924HCID 178453924, compound2×

Product 1

HCID 178453891HCID 178453891, compound

Procedure

The title compound, MS: m/e=462.3 (M+H+), was prepared in accordance with the general method of example 1, intermediate E from a mixture of 5-chloro-3-piperidin-4-yl-benzo[d]isoxazole hydrochloride and trans-[4-(2-oxo-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester (Example 1, Intermediate C).

Sources & evidence

ORD record
ord-81c887429d3a4b36acdd269d8dee7523
Source dataset
uspto-grants-2014_09
Patent number
US08829029B2

Reaction notes

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