HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(bromomethyl)-3-methoxybenzoate → HCID 19822475, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(bromomethyl)-3-methoxybenzoate | HCID 2759828 | — |
| Reactant | HCID 19822474 | HCID 19822474 | — |
| Reactant | HCID 19822476 | HCID 19822476 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Catalyst | HCID 178418751 | HCID 178418751 | — |
| Product | HCID 19822475 | HCID 19822475 | — |
Reaction Steps
The cross coupling process may be carried out, for example, using a stoichiometric amount of activated zinc dust and a catalytic quantity of a transition metal catalyst, such as, for example, dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) or dichlorobis(triphenylphosphine)nickel(II) to couple, for example, 3-bromo-5-(N-cyclopentylmethylcarbamoyl)-1-(carbamoylmethyl)indazole with, for example, methyl 4-bromomethyl-3-methoxybenzoate to afford methyl 4-[5-(N-cyclopentylmethylcarbamoyl)-1-(carbamoylmethyl)indazol-3-ylmethyl]-3-methoxybenzoate: followed by decomposition of the ester to afford 4-[5-(N-cyclopentylmethylcarbamoyl)-1-(carbamoylmethyl)indazol- 3-ylmethyl]-3-methoxybenzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05049576 |
| Source dataset | uspto-grants-1991_09 |
| ORD ID | ord-52a9ee2929394933806dcaa4ce1aed14 |
| Source note | uspto-grants-1991_09 |