Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 14997846, compound

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Reaction Steps

In 6 ml of ethanol was dissolved 0.5 g of 3',5'-bis-O-[N-(2-n-propyl-n-pentanoyl)glycyl]-2'-O-(2-tetrahydropyranyl)-5-fluorouridine, and after adding 18 mg of pyridinium p-toluenesulfonate at room temperature under stirring, the mixtuer was stirred at 55° C. for 3.5 hours. The residue obtained by condensing the reaction mixture under reduced pressure was applied to silica gel column chromatography to give 0.34 g (Yield: 77%) of the title compound.

Provenance & Evidence