Hydrochloric Acid → N-tosyl-bis(2-tosyloxy propyl) amine

Participants

Reaction Steps

A solution of 53.2 g (0.4 mole) of diiso-propanolamine in 50 cm3 of pyridine is added dropwise with cooling to a solution of 248 g (1.3 mole) of tosyl chloride in 200 cm3 of pyridine at 0° C. so that the temperature is maintained between 0° and 5° C. The mixture is left at this temperature for 72 h. It is then poured into 2 l of water plus ice and 250 cm3 of concentrated hydrochloric acid.

Provenance & Evidence