Ethanolamine → HCID 67796390, compound

Participants

Reaction Steps

A flask charged with (±)-cis-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol (0.53 g, 2.00 mmol) from Example 4, triethylamine (0.92 g, 9.10 mmol), ethanolamine (0.172 g, 2.82 mmol) and methoxyethanol (6 mL) was stirred at reflux for 2 hours. The solution was allowed to cool to room temperature before the addition of 2 mL of 1.0 N NaOH. Concentration of the solution left the crude product which was purified by elution from a silica gel column with 10% methanol chloroform (0.430 g, 74%). Crystallization of such a sample from ethanol-water gave a white powder, m.p. 150-152° C.

Provenance & Evidence