Triethylamine → HCID 86745071, compound

Participants

Reaction Steps

A solution of (±)-(cis)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol from Example 4 (0.544 g 2 mmol), triethylamine (0.607 g, 6 mmol) and 6-amino-1-hexanol (0.234 g, 2 mmol) in ethanol (5 mL) was refluxed under nitrogen for 32 hours. During this time additional 6-amino-1-hexanol (0.117 g, 1 mmol) was added. 1 N NaOH (2 mL) was then added and the solution allowed to stir for 30 minutes. The solution was concentrated under vacuum, and the residual oil was dried by evaporation of ethanol and chromatographed on silica gel. Title compound was eluted with 7% methanolchloroform; white powder after crystallization from acetonitrile (0.473 g, 68%), m.p. 120-121° C.

Provenance & Evidence