Hydrochloric Acid → HCID 468292, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of l±)-cis-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol (0.544 g, 2 mmol) in 1-pentanol (10 mL) at 110° C. was added NaH (60% oil dispersion, 0.160g, 4 mmol). The mixture was stirred at 110° C. for 15 minutes, then cooled to room temperature. 1 N HCl was added to adjust the pH to 7.0, and the solvent was removed by evaporation. The residual oil was chromatographed on silica gel. Title compound was eluted with 7% methanol-chloroform; white powder after crystallization from acetonitrile-methanol (0.481g, 76%); mp=139-141° C.;

Provenance & Evidence