Hydrochloric Acid → HCID 86745072, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (±)-cis-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol (0.549 g, 2 mmol) in 1-hexanol (10 ml) at 110° C. was added NaH (60% oil dispersion, 0.16 g, 4mmol). The mixture was stirred at 110° C. for 20 minutes, then cooled to room temperature. 1 N HCl was added to adjust the pH to 7.0, and the solvent was removed by evaporation. The residual oil was chromatographed on silica gel. The title compound was eluted with 7% methanolchloroform; white powder after crystallization from acetonitrilemethanol (0.397 g, 60%); MP 90-92° C.;

Provenance & Evidence