Fumaric Acid → HCID 14536527, compound

Participants

Reaction Conditions

Reaction Steps

Fumaric acid (0.13 g) dissolved in 2-propanol (5 cc) under reflux is added to a solution of 10-[(2RS)-1-diethylamino-2-propyl]-N-ethyl-2-phenothiazinecarboxamide (0.44 g) in boiling 2-propanol (5 cc). Crystallization is primed by scratching and the mixture is stirred for 5 hours at 25° C. The crystals are filtered off on sintered glass, washed with ice-cold 2-propanol (2×3 cc) and dried in the ambient air to give 10-[(2RS)-1-diethylamino-2-propyl]-N-ethyl-2-phenothiazinecarboxamide fumarate (0.51 g), m.p. 135° C.

Provenance & Evidence