Fumaric Acid → HCID 14536547, compound

Participants

Reaction Conditions

Reaction Steps

Fumaric acid (0.13 g) dissolved in 2-propanol (5 cc) under reflux is added to a solution of N-butyl-10-[(2RS)-1-diethylamino-2-propyl]-2-phenothiazinecarboxamide (0.46 g) in boiling 2-propanol (5 cc). Crystallization is primed by scratching, and the mixture is stirred for 5 hours at 25° C. The crystals are filtered off on sintered glass, washed with ice-cold 2-propanol (2×3 cc) and dried under reduced pressure (5 mm Hg; 0.7 kPa) to give N-butyl-10-[(2RS)-1-diethylamino-2-propyl]-2-phenothiazinecarboxamide fumarate (0.34 g), m.p. 129° C.

Provenance & Evidence