Hydrogen Sulfide → HCID 14536559, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbothioamide (1 g) and butylamine (1.5 cc) in absolute ethanol (20 cc) is saturated with hydrogen sulphide and then heated for 24 hours to a temperature in the region of 120° C. After being cooled, the reaction mixture is concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 40° C. The residue is taken up with distilled water (10 cc) and ethyl acetate (25 cc). After extraction, the organic phase is separated, washed with distilled water (10 cc) and then with saturated aqueous sodium chloride solution (20 cc), dried over potassium carbonate, filtered and concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 40° C. N-Butyl-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbothioamide (1.15 g) is thereby obtained in the form of a viscous yellow oil which is subsequently used as it is.

Provenance & Evidence