Fumaric Acid → HCID 86745077, compound

Participants

Reaction Conditions

Reaction Steps

Fumaric acid (0.07 g) dissolved in 2-propanol (1 cc) under reflux is added to a solution of 10-[(2RS)-1-diethylamino-2-propyl]-N-[(2RS)-2-methylbutyl]-2-phenothiazinecarboxamide (0.25 g) in boiling 2-propanol (2.5 cc). Crystallization is primed by scratching, and the mixture is stirred for 2 hours at 25° C. and then left to stand for 12 hours at 0° C. The crystals are filtered off and dried under reduced pressure (5 mm Hg; 0.7 kPa) at 40° C. to give 10-[(2RS)]-l-diethylamino-2-propyl]-N-[(2RS)-2-methylbutyl]-2-phenothiazinecarboxamide fumarate (0.19 g), m.p. at 110° C.

Provenance & Evidence