反应详情

To 25 g (0.25 mol) of 2-ethyl-4,5-dihydrooxazole add 10.0 g (62 mmol) of 4-(1H-imidazol-1-yl)phenol. Reflux the reaction mixture. Monitor the progress of the reaction by thin-layer chromatography on silica gel (9:1, CH2Cl2 :MeOH). Upon completion of the reaction remove the excess starting material by distillation, add ethyl acetate, and wash the solution with 2 N NaOH. Dry the organic layer over anhydrous Na2SO4. Remove the drying agent by filtration and remove the solvent in vacuo. Recrystallization from ethyl acetate-hexane affords the title compound.

1. temperatureReflux the reaction mixture
2. customMonitor the progress of the reaction by thin-layer chromatography on silica gel (9:1, CH2Cl2 :MeOH)
3. customUpon completion of the reaction remove the
4. distillationby distillation
5. additionadd ethyl acetate
6. washwash the solution with 2 N NaOH
7. dry with materialDry the organic layer over anhydrous Na2SO4
8. customRemove the drying agent
9. filtrationby filtration
10. customremove the solvent in vacuo
11. customRecrystallization from ethyl acetate-hexane