反应详情

Add 474 g (2.10 mol) tin chloride dihydrate to a refluxing solution of 125 g (0.420 mol) 4-(4-nitrophenyl)-1-(phenylmethyl)piperazine in ethanol. Reflux the solution for about 15 h then cool to room temperature and remove the solvent. Dissolve the residue in water and adjust to pH 12 withsodium hydroxide. Extract the aqueous solution with methylene chloride and dry the organic layer with anhydrous sodium sulfate. Concentration at reduced pressure gives the title compound.

1. temperatureReflux the solution for about 15 h
2. customremove the solvent
3. dissolutionDissolve the residue in water
4. extractionExtract the aqueous solution with methylene chloride
5. dry with materialdry the organic layer with anhydrous sodium sulfate
6. concentrationConcentration at reduced pressure